Brendan Rodgers has confirmed that defender Jose Enrique is likely to require an operation after providing an update on the injuries in his squad at his pre-Everton press conference on Thursday.
The Spaniard has been struggling with an ongoing knee problem since the opening weeks of the 2013-14 campaign and has not started any of the Reds' last four fixtures in the Barclays Premier League.
"We're just waiting for clarification on his injury, but it looks like he'll probably need a small operation," the manager told reporters at Melwood.
"It's disappointing because he has been out for a couple of months and we've tried various ways to get him back fit. But he's still in pain.
"The conclusion will be that he'll need the operation and we'll assess it from there. I just need to wait and see, wait to hear from our head doctor later on today, and we'll get a better idea of how long that will be."
Rodgers was asked about the fitness of striker Daniel Sturridge, who completed 90 minutes in England's 1-0 friendly defeat by Germany at Wembley earlier this week.
He continued: "He obviously went to England with an injury. He's had a dead leg for about three to four weeks that he has been playing through. He hardly trained when he left, after the Fulham game.
"We'll assess him; he's back recovering after that, with the other international players. We'll see how it is over the next couple of days."
Steven Gerrard was also on international duty with the Three Lions, and Rodgers paid tribute to the 33-year-old for his continuing fitness and longevity.
"It's very simple; he's a brilliant professional," said the Northern Irishman. "He is someone that manages his body really well - he knows he's got a superb medical team here to support that.
"The training methodology helps him because he's working in different spaces and different exercises on a daily basis. That takes away a lot of impact and physicality.
"He just manages himself really well. He knows his body. Over the last 18 months, you only need to look at his record since we came in - it has been very good.
"In big part, that is down to him and his professionalism."
Defender Kolo Toure missed the Reds' last encounter - a 4-0 victory at home to Fulham - but the Ivorian is back in contention for Saturday's trip to Goodison Park.
The boss said: "He's been back training, so there's no problem."