Jürgen Klopp takes on Chelsea boss Maurizio Sarri for the first time on Wednesday night, with Liverpool seeking to gain the upper hand in the clubs' head-to-head record in the League Cup.
The Reds and the Blues are locked together on three wins apiece, plus one draw, in previous meetings heading into the third-round clash at Anfield.
The last time the clubs met on Merseyside in a one-legged League Cup tie was at the same stage of the competition in November 2000, when Liverpool won 2-1 with goals from Danny Murphy and Robbie Fowler.
Gerard Houllier's team went on to beat Birmingham City on penalties in the final.
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
The Reds have won two and drawn one of their three clashes with Chelsea at Anfield in this competition.
Liverpool's last success against the Londoners in a League Cup fixture came in 2011 when Maxi Rodriguez and Martin Kelly scored in a 2-0 win at Stamford Bridge.
Only two of the sides' 87 meetings at Anfield in all competitions have finished goalless - a league clash in 1971 and a Champions League group game in 2005.
Jordan Henderson could play against Chelsea for the third successive League Cup tie having faced them in 2011 and 2015.
Henderson has played more League Cup games for Liverpool (21) than any other current Reds player.
Daniel Sturridge has scored eight goals in eight League Cup appearances for the Reds and has 10 in 14 games in his career.
Two goals will see the striker become the ninth player to reach 10 goals for Liverpool in this competition.
Sturridge's first ever League Cup goal came on Merseyside when he scored an extra-time winner for Chelsea at Goodison Park in October 2011.
Georginio Wijnaldum's next appearance will be his 100th for Liverpool in all competitions.
Mohamed Salah has scored 30 goals in his last 31 Anfield appearances (20 in his last 17) and is one goal away from recording 50 for English clubs during his career, with his first two coming as a Chelsea player.
Only two visiting teams have managed to score in the last 12 Anfield fixtures - Paris Saint-Germain and Roma both scored twice in the Champions League but still lost.