Liverpool U21s will host Chelsea in their first game of 2015-16 at Langtree Park on Sunday August 9 at 2pm BST, after their fixtures for the new season were confirmed today.
Michael Beale's side will play their home games at venues including Langtree Park and Chester FC, plus selected matches at Anfield.
The first mini-derby of the season takes place on Wednesday August 19 when the Reds face Everton away at Southport FC, with the return fixture at Anfield on Sunday December 6 at 2pm.
Anfield will also host the clash with Manchester United on Sunday March 13 at 2pm.
U21 fixtures for 2015-16
Sunday 9 - Chelsea (H) 2pm at Langtree Park, St Helens.
Wednesday 19 - Everton (A) 7pm at Southport FC.
Monday 24 - Reading (A) 7pm at Reading FC.
Sunday 13 - Middlesbrough (H) 2pm at Langtree Park, St Helens.
Monday 21 - Norwich City (A) 7pm at Carrow Road.
Monday 28 - Leicester City (H) 7pm at Langtree Park, St Helens.
Sunday 18 - Sunderland (A) 3pm at Eppleton Colliery Welfare Ground.
Friday 23 - Tottenham Hotspur (A) 7pm at The Lamex Stadium, Stevenage Borough FC.
Sunday 1 - Southampton (H) 2pm at Langtree Park, St Helens.
Saturday 21 - Manchester City (A) 12 noon at City Academy.
Monday 30 - Manchester United (A) 7pm at Leigh Sports Village.
Sunday 6 - Everton (H) 2pm at Anfield.
Monday 14 - Chelsea (A) 7.05pm at Aldershot Town FC.
Monday 11 - Southampton (A) 7pm at Staplewood Training Ground.
Monday 25 - Tottenham Hotspur (H) 7pm at Anfield.
Sunday 31 - Reading (H) 2pm at Chester FC.
Sunday 7 - Manchester City (H) 2pm at Anfield.
Monday 22 - Sunderland (H) 7pm at Chester FC.
Monday 7 - Middlesbrough (A) 7pm at Hartlepool United FC.
Sunday 13 - Manchester United (H) 2pm at Anfield.
Monday 4 - Leicester City (A) 7pm at King Power Stadium.
Monday 25 - Norwich City (H) 7pm at Chester FC.
Supporters should note that these fixtures are subject to change.