Liverpool travel to Brighton and Hove Albion's Amex Stadium on Saturday for what will be the first ever Premier League meeting between the two clubs.
Their last league clash came back in 1983, when Ian Rush scored twice as the Reds came from behind to secure a 2-2 draw at the Goldstone Ground.
There have, however, been plenty of cup clashes in more recent years, so let's take a stroll down memory lane as we look at the last five matches against the Seagulls.
5. Walsh hat-trick stuns Seagulls
Paul Walsh scored the first of his two career hat-tricks for Liverpool in this League Cup third round victory over Brighton at Anfield.
Player/manager Kenny Dalglish completed the scoring on the day, while Walsh remains the only Liverpool player to have ever scored a hat-trick against Brighton.
4. Rush strikes twice as Reds rocked by Brighton
Dalglish's side went in to this match as heavy favourites and when Ian Rush put Liverpool 2-0 up, the match appeared to be over.
However, Mike Small and John Byrne struck within two minutes of each other to level the scores and maintain Brighton's impressive record against Liverpool in the FA Cup, having knocked the Reds out in 1983 and 1984.
3. McMahon and Rush save the day
Having been taken to extra-time in this FA Cup fourth-round replay, Liverpool were just 15 minutes away from going out of the competition before Rush latched onto Peter Beardsley's pass to level the scores at 2-2.
Rushie then turned provider with six minutes remaining to set up Steve McMahon to claim victory with his second goal of the game.
Liverpool had avoided being knocked out of the FA Cup by Brighton for the third time in eight years.
2. Bellamy inspires Reds at the Amex
Craig Bellamy was the star of the show on his second full debut for Liverpool as the Reds became the first visiting team to triumph at Brighton's recently-opened Amex Stadium.
Bellamy, who was brought back to Anfield for his second spell by Dalglish, scored the opening goal, played a major role in the second and also hit the crossbar with a long-range free-kick.
Dirk Kuyt put Liverpool two goals up against the Championship side and pulled out the 'Rocking the Baby' celebration - made famous by Brazil's Bebeto at the 1994 World Cup - following the birth of his son.
1. Rampant Reds hit six
Liverpool appeared to benefit from a hat-trick of own goals as they booked a place in the FA Cup quarter-finals. Brighton's Liam Bridcutt notched two of them, but the defensive midfielder's second was later awarded to Steven Gerrard.
Lewis Dunk scored the other and the Seagull's centre-back is one of only two players who featured in this game - the other being Liverpool skipper Jordan Henderson - that could also play in Saturday's Premier League match at the Amex.
Martin Skrtel, Andy Carroll, Steven Gerrard and Luis Suarez were also on target as Dalglish's side secured a comprehensive victory ahead of a trip to Wembley for the League Cup final against Cardiff City.