Mohamed Salah, Sadio Mane and Marko Grujic will not be involved against the Bundesliga club having only returned to pre-season training on Friday.
Georginio Wijnaldum will be absent, too. The midfielder has recovered from a minor muscle issue that kept him out of the friendlies with Bury and Blackburn Rovers, but has suffered with a virus for the last two days meaning he won't participate against BVB.
Pedro Chirivella also has a minor complaint - a sore back - that will rule him out of the fixture. The young Spaniard underwent a bespoke fitness session in the USA on Saturday.
All other Liverpool players in the tour party are set to be involved against Dortmund, with Xherdan Shaqiri set to join up with the squad next week.