Wales vice-captain Harding has been a regular since joining from Manchester City Women in 2016 but has now decided to leave following the expiration of her contract.
On her spell with the Reds, Harding said: "I have loved my time at Liverpool Ladies and have made some great friends who will remain friends for life. Liverpool Ladies is a big club with some really talented players but I just felt as though I needed a new challenge at this stage in my career.
“I would also like to pay special tribute to the supporters who travel up and down the country to support the team and are some of the best in the league. Liverpool FC is a great club and I will only take great memories from my time here.”
Everyone at Liverpool Ladies thanks Natasha for her valuable contribution since joining the club and wishes her the best of luck for the future.