The Senegal international, who joined Liverpool from Southampton in June 2016, will play his 100th match for the club if selected at the Amex Stadium.
Mane has scored 42 goals for the Reds, against 23 different opponents, but is yet to find the net against Brighton.
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
Liverpool have won 16, drawn eight and lost only four of 28 meetings in all competitions with the Seagulls. At Brighton, the Reds have won six and lost two with five draws.
The three Premier league clashes have seen Liverpool win them all - scoring 10 goals and conceding once.
Mohamed Salah scored the 100th goal in matches between the two clubs to secure a 1-0 Premier League win for the Reds at Anfield earlier this season.
Liverpool are four goals short of recording 50 in the league against the Seagulls.
The Reds have kept two consecutive league clean sheets against today's opponents. They have never secured three in succession.
Virgil van Dijk could make his 50th appearance for Liverpool in all competitions if he features against the Seagulls.
Premier League leaders Liverpool lost to second-placed Manchester City last time out, they have never lost two in a row in the top-flight under Jürgen Klopp.
Current Brighton boss Chris Hughton has lost all six previous meetings with Liverpool as a manager, conceding 25 goals.