The Reds will qualify for the knockout stages of Europe's elite competition with a draw at Anfield in their final match in Group E.
Read on to find out what record Jürgen Klopp's side are closing in on, plus six more pre-match facts and figures from club statistician Ged Rea...
Liverpool have scored 16 goals in the group stage so far this season. The most they have ever hit in a European group stage came in the Champions League in 2007-08, when they netted 18.
Mohamed Salah (17), Roberto Firmino (11), Philippe Coutinho (six) and Sadio Mane (five) have scored 39 goals between them this season, with 15 of those coming in the last six games.
In 2002-03, Spartak and Liverpool met in the Champions League group stage with the Reds winning 5-0 at Anfield. It remains the Russian club's heaviest ever loss in Europe.
Liverpool are unbeaten in their last 12 home games in Europe - winning eight and drawing four.
Joe Gomez could play the 50th game of his professional club career - 24 of which were for his first club, Charlton.
Spartak have scored in all their Champions League group games this season but have not won away from home in Europe in 10 games, since recording a 1-0 win at Ajax in the 2010-11 Europa League.
In seven clashes with Russian sides at Anfield, Liverpool have on ever lost once. Spartak won 2-0 in the Cup Winners Cup second round in 1992-93.