The duo will be assessed ahead of the trip to the King Power Stadium, with Lovren having missed the last two fixtures due to a back problem while Matip sustained a knock against Burnley last Saturday.
Nevertheless, Klopp is confident the Reds' preparations won't be negatively impacted upon by the doubts.
Asked how his side would set up if both were to be ruled out, the manager replied: “It would be the third game in a row for Ragnar if he plays again. Joe made a game in the centre-half position, so then we would have to see how we can manage it if it was to be like this. I don’t hope it is like this.
“Then Trent probably plays again at full-back and three days later again because Joe is suspended, stuff like this – it’s a normal day for a football manager.
“We will have to see what we can do, but until I know it is not verified how it is exactly. I have to wait and we have to train with the boys if they can train today.
“Then we will prepare for the game and then we will see until Saturday, but there are still two days to go to see which players will be available.
“It is a normal challenge, it’s not that it’s worse or better than the other situations. It’s how it is. Players can get ill overnight and then you have to make another plan. That’s why we prepare pretty much everything when we know who we can use.”