Steven Gerrard’s side have been drawn alongside Boro, West Ham United and Sunderland in this year's tournament, and will need to top Group D to ensure a place in the quarter-finals.
The two best second-placed teams in the six groups will also claim a last-eight berth.
Read on for all the details you’ll need about the U18s’ next fixture.
Where is the game being played? The match is at the Kirkby Academy with kick-off set for 12.30pm BST.
How can I watch the game? Extended highlights will be available on LFCTV GO on Monday. Click here for details on how to sign up.
Last season head-to-head: The young Reds lost their last away game againt Middlesbrough, Rhian Brewster netting in a 2-1 defeat.
However, they exacted revenge in December's return fixture, with Brewster scoring twice in a 2-1 victory.
Classic encounter: August 22, 2015. Middlesbrough were reigning U18s Premier League champions and showed their quality by running up a 3-0 lead at Kirkby. However, Toni Gomes had other ideas and netted a fantastic hat-trick to level the scores.
Yan Dhanda then grabbed a superb late winner as the young Reds recorded a memorable 4-3 victory. Watch highlights of that game below.