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Brendan Rodgers admits Philippe Coutinho will be sorely missed after the Liverpool midfielder underwent surgery on his shoulder.
The Brazilian is facing six weeks out following the injury he suffered in Monday's 2-2 draw with Swansea City.
"It's unfortunate for him because he's been in great form since he came here in January," Rodgers said.
"The challenge was probably a bit clumsy but it was actually more the fall that did the damage. In those scenarios the bone may be bruised but unfortunately for Philippe the bone came through the muscle. That's what the pain was and why the operation was needed.
"He was a really pivotal player for us in the game. When he went off, we lost that connection between our midfield and the front line. It disrupted our balance a bit.
"Hopefully he'll recover quickly and come back to us in good shape."
Rodgers hopes to have Daniel Agger back available for tomorrow's clash with Southampton at Anfield. The Danish centre-back missed the game at the Liberty Stadium with a side strain.
"We'll see how Daniel is in the next 24 hours," he said.
"It's too early to say if he'll be ready for the weekend but we're hopeful he'll be fine."
Aly Cissokho has stepped up his recovery from ankle ligament damage. The on-loan left-back was back jogging at Melwood yesterday and is around two weeks away from a return to action.
Glen Johnson is still wearing a protective boot on his injured ankle and is unlikely to make a comeback until late October.
Rodgers admits Martin Kelly staked a claim for the right-back spot with his display for the Under-21s against Sunderland on Tuesday night.
"Martin was excellent and definitely stepped up a level in terms of his fitness," he added.
"He was out for a long time and you have got to nurture him back. He's getting close and he'll be a great one to have back in the team because he's an experienced player."