The Liverpool fans can make all of the difference as the Reds try to reverse their deficit against Zenit St Petersburg on Thursday night, according to centre-back Martin Skrtel.
Brendan Rodgers' side trail the Russians 2-0 after last week's first leg away from home, with late strikes by Hulk and Sergei Semak at the Petrovsky Stadium leaving the Reds with work to do.
But the Slovakian, who played for Zenit before arriving at Anfield five years ago, is confident the tie can be turned around with the help of a sell-out Liverpool crowd.
He told Liverpoolfc.com: "The atmosphere at Anfield in European games is always special and the game on Thursday will be even more because we lost the first game and the crowd feel we need their help. I'm pretty sure they will help us.
"In football everything is possible. We'll play at Anfield - we know the fans will be behind us and they'll help us to get into the next round.
"It's not going to be easy but if we can get an early goal that will help us a lot. Then just try to play our game, create chances and take them. We believe we can beat them at home."
For 70 minutes in Russia the Reds were comfortable, although talisman Luis Suarez endured a frustrating evening by uncharacteristically missing a succession of chances.
That Rodgers' men managed to fashion such opportunities should be cause for optimism, though, says Skrtel.
"It could be better. We lost the first leg 2-0 and that was not the best result for us," he continued.
"But we've still got to play at Anfield - as we lost there 2-0, the same can happen to them at Anfield. We still have a shot and we will do everything possible and try our best to get a result and get us to the next round.
"We controlled the game and created four or five chances. Unfortunately we couldn't take them and score a goal. That gives us belief for the next game - we created chances away so we'll definitely create them at home. We just need to take them."
Skrtel played the full 90 minutes of the first leg at Zenit - the first time he has featured against his former club since leaving Russia in 2008.
"It was something special, and strange, because it was the first time since I left Zenit that I came back as a player for the other team," the 28-year-old explained.
"Apart from the result, I enjoyed everything about the game - I just feel bad about the result. We have one more game to play against them and I hope we can get the result."