If Steven Gerrard features against Zenit St Petersburg on Thursday, the Reds captain will rise to ninth on the club's all-time appearance list.
For that and 22 other fascinating facts about our clash with the Russians, read Ged Rea's pre-match stat pack...
Gerrard is one goal away from equalling Michael Owen's club record of 12 goals in the competition. His next goal in Europe will be his 40th for the club.
If Stevie scores three he will be the first player in the club's history to score three European hat-tricks.
His next goal will see him equal Owen's tally of 158 goals for the club.
His next appearance for the club will see him overtake Alan Hansen's 620 games for the Reds and put him in ninth place on the club's all-time appearance list.
Liverpool are aiming to overturn a two-goal European first leg deficit for only the second time in their history. On the other occasion, current first-team coach Mike Marsh was on target as Liverpool beat Auxerre 3-0 at Anfield in the UEFA Cup in November 1991 to win the tie 3-2. Jan Molby (penalty) and Mark Walters were the other scorers, with the decisive goal coming in the 84th minute.
In all European competitions the Reds have faced a deficit of at least two goals in 11 ties previously, with 10 of the second legs coming at Anfield. Ajax, Nottingham Forest, Anderlecht, Widzew Lodz, Genoa, Spartak Moscow, Paris Saint-Germain, Strasbourg, Celta Vigo and Chelsea have all succeeded in progressing.
The last time Liverpool needed to come back from a two-goal first leg deficit was in April 2009 when in the Champions League quarter-final they lost 3-1 at home to Chelsea. They so nearly pulled it off at Stamford Bridge in the return only to draw 4-4 on the night.
In those 11 ties, Liverpool have won the second leg five times, with three draws and three defeats. The only away second leg was at Chelsea.
The last time Liverpool played in Europe on this date was six years ago, when they pulled off a stunning 2-1 Champions League win over Barcelona in the Nou Camp.
Liverpool have scored three goals in only one of their last eight home games in Europe - against Gomel back in August.
The Reds have kept five clean sheets in their last eight European games at Anfield.
Liverpool have not conceded a goal to Russian teams in their last three Anfield meetings.
This is the only tie of the Round of 32 which features two previous winners of the UEFA Cup/Europa League.
There are 10 previous winners of this competition in its three various guises in this Round of 32.
The teams in the Round of 32 come from 16 different countries, with England and Germany producing the most - four.
Liverpool and Inter Milan are hoping to win the Fairs Cup/UEFA Cup/Europa League for a record fourth time.
The last Liverpool player to score a hat-trick in this competition at Anfield was Gerrard against Napoli in 2010. That is the last of 17 scored by Reds players in Europe.
Stewart Downing has featured in all 11 matches in Europe this season - the only Reds player to do so. Tonight could see him play the 400th game of his club career.
Jamie Carragher could make his 150th European appearance for Liverpool in this game.
Pepe Reina is one clean sheet away from equalling Ray Clemence's club record of 39 in Europe in a Reds career.
Daniel Agger could play his 200th game for Liverpool in all competitions. He has appeared in Europe only three times this season.
The Reds have kept 10 clean sheets in 20 home games this season.
They have only lost one of their last 16 European games at Anfield.