Luis Suarez will clock up a 100th appearance in the Barclays Premier League if he features against Southampton on Saturday - take a look through our statistics pack for more pre-match facts and figures.
Suarez could play his 100th Premier League game for Liverpool today; he has scored 61 goals in the top flight. The Uruguayan missed the clash with Southampton at Anfield earlier this season.
Raheem Sterling, meanwhile, could reach the milestone of 50 league games for Liverpool.
Daniel Sturridge has scored in eight Premier League games in a row. Only twice in history has this feat been achieved previously - both by Ruud van Nistelrooy. The Dutchman also holds the record of 10.
Liverpool's last win at St Mary's occurred in January 2003, when Emile Heskey scored the only goal of the game on 14 minutes. The Reds have won only one of their last seven visits to Southampton.
There has never been a goalless draw in the 38 league meetings at Southampton. The only two in 77 league meetings have come at Anfield, with the last in May 2000.
No Liverpool player has scored a hat-trick at Southampton, with only Robbie Fowler (twice) scoring three in a game against the Saints - both at Anfield, in October 1993 and January 1999.
The only Saints player to score a hat-trick against Liverpool was Matthew Le Tissier - his tally included two penalties in a 4-2 win at the Dell in February 1994.
Steven Gerrard has scored 42 away league goals for Liverpool. The only Reds players to score more away from Anfield in the Premier League era are Michael Owen (55) and Fowler (43).
The Reds have scored 28 away goals in the league so far this season, the most of any top-flight team going into this round of fixtures. Only in five full seasons have they scored more on the road in the Premier League era. Their most was 38 - last season.
Brendan Rodgers' team have scored 70 league goals this season, one more than Manchester City, and the highest total in all four divisions. Their goal difference of +35 is their highest at this stage of any Premier League campaign.
Last Sunday, against Swansea City, Liverpool set a new Premier League record by scoring a 46th goal before half-time. That broke the previous record set by Arsenal (2002-03) and Manchester United (2012-13), who had netted 45 in a full campaign.
Only Southampton and Arsenal have prevented Liverpool from scoring in 27 league games this season, with only the Gunners keeping a clean sheet against a visiting Reds team.
Liverpool's current tally of 56 points is their best ever after 27 games of a Premier League campaign. After 27 games last season, the Reds' current points tally would have been good enough to be second on goal difference and nine points ahead of fifth place.
Southampton have kept 10 clean sheets this season, compared to Liverpool's seven. The Saints have scored in 14 of their last 15 league games, with only Chelsea managing to shut them out.