Virgin Trains has announced that planned engineering works will take place on Saturday evening which will impact on Liverpool fans returning from Arsenal after the game.
The works will take place between Weaver Junction and Warrington, starting at 6pm, meaning all later Liverpool trains will terminate at Crewe and coaches will be provided to complete the journey to Liverpool Lime Street.
Bob Humphries, chair of the official Liverpool FC Supporters' Committee, has written to Virgin Trains on behalf of Reds fans to express their disappointment.
He said: "Our game against Arsenal kicks off at 5.30pm, meaning our travelling fans will already have a late enough return without the extension of a bus service between Crewe and Liverpool.
"I have written to Virgin Trains to express our disappointment at the timings of these works and asked them to consider the possibility of delaying the start of the works until the last train to Liverpool Lime Street has completed its journey.
"Unfortunately, Virgin has confirmed that the timings cannot be changed, so we need to let all our fans know so they can plan accordingly."