Having cruised into the knockout stages of the youth competition with a 100 per cent record, Spain came unstuck against the South Americans - an extra-time winner from Felipe Avenatti the only goal.
Suso featured in all five of his country's matches and impressed with his creativity in a talented squad of youngsters, but will have to settle for a new maturity rather than a medal.
"I think we have to learn from every moment, from every point of the tournament," the 19-year-old explained to FIFA.com post-match.
"I think this will obviously be the biggest one, and it will be a learning experience for all of us.
"We got nine points in the groups, but in the knockout stages we came up against the toughest teams we could have, I think, in Mexico and Uruguay.
"This is football, and if you want to win a World Cup you have to beat the best teams. We tried to do that today, but luck just wasn't on our side.
"I think we played some good football, but in the first half both teams were playing really well. However, Uruguay were waiting for us to come at them and defended, which made it difficult for us to work through them in the first half.
"In the second half, though, I think we were the better side; the only real chance they had from then on was from the corner where they scored."