Liverpool host Tottenham Hotspur at Anfield on Sunday afternoon as the clubs go head-to-head for the 170th time.
There have been some great tussles with Spurs down the years and more than a few players have experienced both sides of the battle.
Kop icons such as Graeme Souness and Ray Clemence once also called White Hart Lane their home ground.
In total, 22 players have turned out for both clubs, but can you name all 13 to have done so in the Premier League era?
Let us help you out....
1. Neil Ruddock
Ruddock became the first player to make the switch in the Premier League era when Souness signed him from Spurs in 1993.
An uncompromising centre-back, 'Razor' had an incredible will to win, could hit some fantastic passes upfield and was great in the air.
He famously riled Manchester United's Eric Cantona by repeatedly turning down the Frenchman's collar and further endeared himself to Kopites when he scored a courageous late header to earn a 3-3 draw against the Red Devils in 1994.
2. Ronny Rosenthal
Signed by Kenny Dalglish, Rosenthal had scored seven goals on loan as Liverpool won the title in 1990 and was already at the club when the Premier League began in 1992.
A cult hero among fans, 'Rocket Ronny' netted 22 times in all, including a perfect hat-trick on his full debut and an injury-time winner in the Merseyside derby against Everton at Anfield in 1993.
He joined Tottenham a year later, in 1994, and fired in a famous FA Cup hat-trick against Southampton, with a certain Bruce Grobbelaar in goal for the Saints.
3. Jamie Redknapp
A superbly talented midfielder and brilliant passer of the ball, former Liverpool skipper Redknapp was a popular figure at Anfield.
Snapped up as a fresh-faced 17-year-old by Dalglish in January 1991, he would eventually make his Reds debut 10 months later under new manager Souness.
He helped LFC win the League Cup in 1995 and the England international could have won more during his 12 years at Anfield were it not for injuries.
He left Liverpool to join Glenn Hoddle's Tottenham in 2002 and was made club captain by his former England boss.
4. Christian Ziege
A Scudetto winner at AC Milan in 1999, Germany international Christian Ziege was regarded as one of the best left-backs in Europe when he joined Gerard Houllier's Liverpool, via Middlesbrough, in 2000.
He never really hit top form at Anfield, but was part of the squad that clinched the 2001 cup treble in his one and only season with the Reds.
He moved on to Tottenham and later helped an unfancied Germany team reach the final of World Cup 2002.
5. Peter Crouch
Crouch proved to be a popular figure at Anfield after Rafa Benitez signed him from Southampton in 2005.
Although he took his time to notch his first Liverpool goal, the 6' 7" striker famously scored a perfect hat-trick - left foot, right foot and header - as the Reds beat Arsenal 4-1 in 2007.
His stunning overhead kick in a 3-2 Champions League win over Galatasaray was voted into UEFA's top 10 all-time goals in European competitions.
After leaving the Reds in 2008, he returned to Spurs via Portsmouth, where he had come through the youth ranks, and later scored the winner against AC Milan in a Champions League tie at the San Siro.
6. John Scales
Having been named as a substitute for Wimbledon in their famous FA Cup win in 1988, it was Roy Evans who brought stylish centre-half Scales to Anfield.
Nicknamed 'Bond' by his Reds teammates, he was cool under pressure and won a medal in his first season as Liverpool lifted the League Cup in 1995.
He joined Tottenham a year later and was re-united with manager Gerry Francis, who he had played for at Bristol Rovers, and scored one goal for the club - against Liverpool.
7. Robbie Keane
Keane joined Liverpool from Tottenham in 2008 and although it didn't quite work out how he would have liked it at Anfield, the boyhood Red did score seven goals in 28 games.
The pick of his strikes was probably his thundering half-volley against old north London rivals Arsenal. However, he struggled to replicate his best form alongside Fernando Torres and returned to Spurs six months after joining the club.
8. Brad Friedel
Signed by Evans, USA goalkeeper Friedel joined Liverpool from MLS side Columbus Crew back in 1997 after rejecting approaches from Celtic and Rangers.
Friedel started the 1998-99 season as Liverpool's first-choice 'keeper, but he lost his place to David James and, in November 2000, made the switch to Blackburn Rovers.
At Ewood Park, Friedel established himself as one of the top stoppers in the Premier League and spent the last four years of his lengthy playing career at Tottenham, via Aston Villa, before retiring in 2015.
9. Paul Konchesky
Left-back Konchesky spent time on loan at Spurs in 2003 after handing in a transfer request at Charlton Athletic, but the move was never made permanent.
Signed from Fulham by Roy Hodgson on transfer deadline day 2010, Konchesky found it tough to establish himself under new boss Dalglish in 2011.
He was loaned out to Nottingham Forest before joining Leicester City, where he became a key figure as they won promotion to the Premier League in the 2013-14 season.
10. Danny Murphy
Murphy was signed by Evans from Crewe Alexandra and went on to become a vital player as Liverpool won the cup treble in 2000-01.
And who can forget Super Dan's three Old Trafford winning goals for the Reds?
His free-kick in front of the Stretford End in December 2000 gave Liverpool victory at Manchester United for the first time in 10 years.
Deemed surplus to requirements by manager Rafa Benitez, Murphy moved to Charlton Athletic in 2004 and then onto Spurs at the end of the 2006 January transfer window.
11. Nick Barmby
After emerging from the club's youth ranks, Barmby starred at Tottenham alongside the likes of Jurgen Klinsmann and Ilie Dumitrescu as Ossie Ardiles introduced an all-out attack style at White Hart Lane.
After a spell with Everton he made the short trip across Stanley Park in 2000 and in doing so became the first player to make the move directly from the Toffees to Liverpool since Dave Hickson in 1959.
His time at Anfield was relatively short-lived, but Barmby was part of Houllier's treble-winning side in 2001, scoring four goals in the UEFA Cup en route to claiming a winner's medal.
12. Oyvind Leonhardsen
Signed from Wimbledon in 1997, Norway international Leonhardsen was a first-team regular under Evans during his first season at Anfield.
However, the industrious midfielder with an eye for goal became a bit-part player under Houllier and was sold to George Graham's Spurs in 1999.
He spent three years at White Hart Lane before joining Aston Villa in 2002 and returning to his homeland with Oslo club Lyn two years later.
13. Steven Caulker
Defender Caulker came through the ranks at Tottenham and made his senior debut under Andre Villas-Boas in 2012 before being snapped up by newly-promoted Cardiff City for a club-record fee a year later.
He made four appearances for Liverpool in January 2016 during a short-term loan from Queens Park Rangers to help ease an injury crisis for manager Jürgen Klopp.
The centre-back featured as an emergency striker - against Arsenal, Manchester United and Norwich City - during his brief Anfield stay.