Luis Suarez scored twice as Uruguay beat England 2-1 in the World Cup Group D encounter – a game in which eight Liverpool players featured.
The Reds No.7 marked his first appearance of the tournament with a goal in each half to claim a clinical brace in what proved to be an absorbing encounter.
The game in Sao Paulo got underway with six Liverpool players on the field; Steven Gerrard, Daniel Sturridge, Raheem Sterling, Glen Johnson and Jordan Henderson lining up for England, while Suarez started for Uruguay.
Much of the pre-match chatter centred on the Anfield striker and in a frantic opening, he almost made his presence immediately felt when he attempted to net directly from a corner, which Joe Hart was required to bundle to safety.
A frenetic opening soon gave way to a more measured affair, with chances hard to come by at both ends.
On the half-hour mark, Gerrard's deep free-kick from the left was headed against the crossbar by Wayne Rooney, who had earlier clipped a free-kick inches wide from the edge of the area.
However, on 39 minutes, the South Americans took the lead when Edinson Cavani delivered a pinpoint cross onto the head of Suarez, who netted with a neat nod into the corner.
England could have instantly drawn level, but Sturridge's powerful near-post blast was repelled by the fists of Fernando Muslera.
Moments into the second period, Suarez again attempted to net directly from a corner but was thwarted by Hart once more. The England stopper was called into action moments later, saving well from Cavani.
England's response saw Rooney's drive from Leighton Baines' centre superbly blocked by Muslera.
Then, with 15 minutes remaining, Sturridge and Johnson combined for the Three Lions' leveller when the former sent the latter into space down the right. The full-back cut inside before sliding a pass across the face of goal for Rooney to tuck in.
England were in the ascendancy, but the restored parity did not last long as Suarez latched onto a long loose ball to race into the area and slam beyond Hart from a tight angle.
Hodgson sent on Rickie Lambert as England looked to grab an equaliser, while Sebastian Coates entered the action Uruguay, but La Celeste held on to claim the win.