Here are all the important pre-match stats and facts ahead of this weekend's visit of Tottenham.
On the opening weekend of the season the Reds lost 2-1 at White Hart Lane. Benoit Assou-Ekotto opening the scoring close to half time before Steven Gerrard equalised from the spot on 56 minutes. Sebastien Bassong, making his Spurs debut, netted the winner three minutes later.
Liverpool are unbeaten in 15 league games at home to Spurs - winning ten and drawing five.
The Reds have lost two of the last 11 home and away against Tottenham in the league - and three of the last 15.
Liverpool are three goals short of recording 350 in league games under Rafa Benitez.
Liverpool's last hat-trick against Spurs was scored by Phil Boersma at Anfield in 1974. It is the last of four scored against the Londoners in the league.
If Tottenham fail to score the Reds will keep a third successive league clean sheet for the first time this season.
Steven Gerrard's goal against Wolves on Boxing Day took him into 11th place in the club's leading goalscorer charts. It was his 125th strike in all competitions and his goal at Reading last weekend leaves him two goals behind 10th placed Sam Raybould.
Liverpool require four goals to reach 550 in all competitions under Rafa Benitez.
Since the inception of the Premier League Liverpool have won 16 and lost nine of the 35 meetings home and away.
Steven Gerrard has scored the club's first league goal of a calendar year in four of the last nine seasons.
The Reds have never lost to both North London rivals Tottenham and Arsenal at Anfield in the same league campaign.
Robbie Keane has scored each of Tottenham's last four goals on this ground - he scored four league goals for Liverpool at Anfield during his short Reds career.
Tottenham are looking for only their third league double over Liverpool since 1912. The last came in 1986-87 and they look for only their 5th in the meetings with the Reds.
Spurs last win here came on 25th August 1993 when Teddy Sheringham scored twice in a 2-1 victory. Since then they have picked up five points out of a possible 45.
Tottenham's heaviest defeat at Anfield came in September 1978 when they lost 7-0. It is still the club's biggest ever League defeat.
All five of Tottenham's league wins on this ground have been by the odd goal.
Robbie Keane scored five goals against Liverpool in the Premier League. Only seven players have scored more. He played 28 times for Liverpool scoring seven times.
Peter Crouch made 134 appearances for Liverpool scoring 42 goals including 11 in the European Cup. Only four players have ever scored more goals for the Reds in Europe's premier club competition.
Benoit Assou-Ekotto and Sebastien Bassong have only scored one goal for Tottenham. They came in the same game - against Liverpool on the opening weekend of this season.
Tottenham have lost just one of their last nine league games (at home to Wolves last month) and are unbeaten away from home since losing 3-0 at Arsenal in late October.
They have won four of their 10 away games in the league this season - 5-1 at Hull, 2-1 at West Ham, 2-1 at Portsmouth and 2-0 at Blackburn.
Their two away defeats have come at Chelsea and Arsenal, both by a 3-0 scoreline.
They have not conceded a league goal in the last seven hours and 27 minutes of football (447 minutes) since Kevin Doyle of Wolves scored at White Hart Lane. They also kept a clean sheet against Peterborough in the Cup last weekend.
Spurs are 17 points better off than they were at the same stage last season.
Spurs have kept one clean sheet in the last 13 visits to Anfield and two in the last 22 in the league on this ground.
Since 1912 Spurs have won only three times in 63 league meetings at Anfield. They came in 1985, 1986 and 1993.
Only Garth Crooks, Clive Allen and Teddy Sheringham have scored league goals in winning Tottenham teams at Anfield in the last 97 years.
Tottenham's last hat-trick against the Reds was scored by Jimmy Greaves who scored four at White Hart Lane in 1963.
Niko Kranjcar has scored four goals in his last four starts for the club.
Jermain Defoe has found the net nine times in his last nine league starts with five coming in one game against Wigan.
Spurs have missed two penalties this season - both against Everton. Robbie Keane saw his kick saved at White Hart Lane in the Carling Cup but scored from the rebound while Jermain Defoe also failed to beat Tim Howard at Goodison in the league.