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Alex Inglethorpe's U21s take on West Ham United at Upton Park - a game you can watch exclusively live on LFC TV and LFC TV Online.
Like Liverpool, the Hammers won their respective league section to earn the right to play in the Barclays Premier U21 elite league.
Nick Haycock is in charge of the West Ham side.
The last meeting between the two teams was March 11 when the Hammers grabbed a stoppage time equaliser in a 3-3 thriller.