Please click here to download the latest version of Flash Player to view the match centre.
Alex Inglethorpe's U21s take on Southampton in the Barclays Premier U21 elite league, at St Mary's Stadium - a game you can watch exclusively live on LFC TV and LFC TV Online from 6.45pm GMT.
It is a great chance for the youngsters to play at a first-team stadium and Inglethorpe will be hoping his side can bounce back from the defeat by Manchester United.
With injuries to key players Inglethorpe will be relying on his young players to rise to the ocassion and step-up at U21 level.
Back in January Liverpool beat the Saints 1-0 at the Academy when Daniel Pacheco's effort was deflected into his own net by Jordan Turnbull.