Alex Inglethorpe's U21s take on West Ham United at Rush Green Stadium, the home of Grays Athletic FC - a game you can watch exclusively live on LFC TV and LFC TV Online.
Like Liverpool, the Hammers won their respective league section to earn the right to play in the Barclays Premier U21 elite league.
Nick Haycock is in charge of the West Ham side following his recent promotion from the U18s.
The last meeting between the two teams was October 5, 2010, when the Hammers won 1-0 at Prenton Park thanks to a goal from Benni McCarthy. The likes of Conor Coady, Jack Robinson, Daniel Pacheco and Jon Flanagan played in that game while Suso was on the bench.