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Liverpool's U21s lost their first league fixture of the 2012-13 campaign with a 1-0 defeat at Tottenham.
The young Reds had been on a 14-match unbeaten run but fell on Monday to a goal from Jonathan Obika.
Krisztian Adorjan went close with a free-kick and Conor Coady struck a post but Alex Inglethorpe's side could find no way back into the match.
Spurs lead the way in the Elite Group section, having now won three out of four games.
Liverpool team: Ward, McLaughlin, Robinson, Sama, Coady, Roddan, Suso, Teixeira, Adorjan, Pelosi, Ibe (Nacho).