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Rodolfo Borrell's unbeaten U21s take on Middlesbrough at the Kirkby Academy - a match you can watch exclusively live on LFC TV and LFC TV Online from 1.30pm.
Borrell's charges are the only unbeaten U21s side in the country and go into the game on the back of the 3-3 draw with Chelsea when they let a three goal lead slip.
Back on October 8, a superb goal from Adam Morgan gave the Reds a 1-0 win over Middlesbrough at the Riverside Stadium, and they will be looking to continue their excellent form again on Friday.
Kick-off at the Academy is at 2pm GMT.