Alex Inglethorpe's U21s take on Southampton in the Barclays Premier U21 elite league, at St Mary's Stadium.
It is a great chance for the youngsters to play at a first-team stadium and Inglethorpe will be hoping his side can continue their excellent form.
Back in January Liverpool beat the Saints 1-0 at the Academy when Daniel Pacheco's effort was deflected into his own net by Jordan Turnbull.
