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Steve Cooper's side head to London for a tricky test against Tottenham Hotspur - kick-off is at 11am BST, and the final game before the FA Youth Cup semi-final with Chelsea.
Back at the Academy on March 27 the two sides played out an entertaining 2-2 draw with Daniel Trickett-Smith firing a stoppage time equaliser.
Tottenham have had an excellent Academy season so far and they are flying high at the top of the league, but the Reds can close the gap with a victory.
Cooper's charges will be hoping to bounce back after the 4-1 defeat by Stoke City last weekend.