Steve Cooper's U18s take on Stoke City at the Kirkby Academy - a match you can watch exclusively live on LFC TV and online from 10.45am GMT.
Kick-off is at 11am and join Claire Rourke alongside Roy Evans and Mark Wright.
Cooper's charges go into the game on a six-game unbeaten run and full of confidence after the deserved draw with Tottenham on Wednesday.
Daniel Trickett-Smith's injury time equaliser gave the Reds a 2-2 draw and it keeps alive their chances of making the end of season play-offs.
The result moves Liverpool up to third in Group One, on 11 points - three points behind leaders Tottenham and Sunderland who have 14 points.
Cooper’s side also have two games in hand over Spurs and Sunderland.
Stoke are second from bottom, sixth in a table of seven teams.
The last meeting between the two sides was December 3 2011 when the two sides drew 0-0 in Kirkby. In the return game at Stoke, Reds won 3-1 with Adam Morgan, Kris Peterson and an own goal on target.
Stoke U18s only victory so far in group one was a 3-2 win at home to Tottenham.
