An opening day thrashing at Sunderland's Roker Park hardly boded well for a renewed assault on the league title, but Liverpool recovered from the 3-0 reverse to bring a third Championship back to Anfield.
The close season saw manager David Ashworth draft in Manchester United winger Fred Hopkin for a hefty £2,800, and the Yorkshireman proved an effective ever-present as the Reds brought sides such as Bradford, Huddersfield, Preston and Aston Villa to heel.
Up front, Harry Chambers and Dick Forshaw battled it out for the title of top scorer, netting an impressive 21 and 20 respectively.
The biggest win of the league campaign came in front of 50,000 supporters at Anfield, Chambers claiming a hat-trick in a 5-1 demolition of high-flying Cardiff. At the other end of the spectrum, a 4-0 defeat at Oldham's Boundary Park was hard to swallow.
Still, despite losing two of the final three games of the season, Liverpool ended 1921-22 as comfortable champions, six points ahead of second-placed Tottenham.
To make things even sweeter, north-west rivals Manchester United were relegated after finishing bottom.