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The 224th Merseyside derby sees Liverpool head to Goodison Park to meet Everton in search of a fourth consecutive Barclays Premier League victory.
Brendan Rodgers' men have beaten Sunderland, Aston Villa and West Ham United without conceding a goal in their previous three league outings.
They also booked dramatic progress to the FA Cup fifth round with a stunning late comeback to overcome Bolton Wanderers on Wednesday evening.
Earlier this season, the Reds drew 1-1 with the Blues at Anfield, while last season's corresponding encounter was a thrilling 3-3 result.