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Liverpool U18s host Manchester United at the Kirkby Academy and you can watch the game live on LFC TV and LFC TV Online from 10.30am GMT. Kick-off is at 11am.
The two teams didn't face each other at U18 level last season due to the league format restructuring.
The last time the two sides faced each other was the 2011-12 season when Liverpool did the double winning 2-1 away (Jack Dunn 2) and 2-1 at home.
The previous season Liverpool also did the league double - winning 6-0 at home which was revenge for the FA Youth Cup quarter-final defeat and a 2-1 away win in the league.