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Neil Critchley's Academy youngsters take on Aston Villa in the FA Youth Cup fourth round at St Helens Langtree Park.
Kick-off is at 7pm GMT and you can watch the game exclusively live on LFC TV and LFC TV Online.
The young Reds beat Blackpool in the third round on penalties on a wind swept night on the seaside while Villa overcame Plymouth 4-3 at Villa Park.
The tie has to be decided on the night with extra-time and penalties if necessary.