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Neil Critchley begins life in charge of Liverpool U18s with a trip to London.
It is a repeat of last season's FA Youth Cup semi-final which saw Chelsea beat the Reds over two legs.
So far this season it has been a defeat and a win for the U18s with a 2-1 loss at Arsenal being followed by a superb 1-0 derby win over Everton.
Kick-off at Chelsea's Academy is at 11am BST.