Ahead of this evening's fixture, Scott Rogers' side sit third in the table - four points ahead of the Gunners - so the stakes are high.
After a 5-0 win over Watford in the Women's FA Cup fourth round on Sunday, the Reds go into this clash full of confidence.
Read on for more details...
Where is the game being played? The match is at the Select Security Stadium in Widnes, with kick-off set for 7pm GMT.
How can I watch? We will have highlights on LFCTV in the coming week. If you plan to attend the game, click here for ticket details.
View from the manager, Scott Rogers
"We face a run of some tough matches on paper with Arsenal at home followed by a trip to Manchester City, which will certainly test us. We normally try to focus on one game at a time but unfortunately the schedule dictates that we can't do that. We just have to get on with it and it's the same for every manager and every club. For us, we have to make sure we prepare right and manage the squad over the coming week. In effect we have three tough games in a week, so we will have to be capable of competing in all of these games. It will be an interesting but exciting week to look forward to and we need to be at our best."