Scott Rogers' fifth placed side are two points clear of the Blues and will be looking to take another vital win.
Here's everything you need to know ahead of the Women's Super League fixture...
Where is the game being played? The match is at the Select Security Stadium in Widnes, with kick-off set for 5.30pm GMT.
How can I watch the game? Click here for ticket details. We will have highlights next week on LFCTV.
View from the player, Gemma Bonner
"We can't thank our fans enough for the amount of miles that they have put in supporting us. The last couple of weeks they have followed us to Sunderland and Durham and their support is unbelievable for us as players. We appreciate them so much and we want to get the three points on Saturday against a good Birmingham City Women FC side. We know nobody likes coming to our ground but that is something we’ve got to take advantage of, especially with the brilliant backing we have."