Steven Gerrard's unbeaten side are in great form heading into the game and reached the fourth round of the FA Youth Cup with a thumping 5-1 win at Hartlepool United last Wednesday.
It's tight at the top of the U18 Premier League with the young Reds just two points behind leaders Manchester City.
After drawing their last two league games, Gerrard's team will aim to sign off the year with victory at Wolves.
Read on for all the details you need about Tuesday's fixture...
Where is the game being played? The match is at the Jack Hayward Training Ground at Wolves, with kick-off set for 12pm GMT.
How can I watch the game? We will have live, single-camera coverage of the match on LFCTV GO from 11.55am. Click here to find out more.
Last season head-to-head: In November 2016 the two teams played out a 2-2 draw at Molineux. Rafael Camacho scored a stunning free-kick and George Johnston was also on the mark.
Back in February, meanwhile, the young Reds beat Wolves 3-1 at the Kirkby Academy with Camacho, Glen McAuley and Okera Simmonds among the goals.