Neil Critchley's side go into the game two points clear of the Blues, who won the division last season.
Here's everything you need to know ahead of the mini-derby...
Where is the game being played? The match is taking place at Prenton Park, home of Tranmere Rovers FC, with kick-off set for 7pm GMT.
How can I watch the game? We are showing the match live on LFCTV and LFCTV GO, with our coverage starting at 6.30pm. Click here to sign up now.
If you want to go to the game, admission is free for season ticket holders and LFC Members simply by showing your card, otherwise it's just £3 for adults and £1 for children on the gate.
View from the manager, Neil Critchley
"We are looking forward to playing on a Saturday night under the floodlights at Prenton Park. It's a different time to what we would normally play, but sometimes you have to move the games around to work around the different schedules you have.
"It's a really exciting game in prospect with us first and Everton in second place so it's one we are really looking forward to. We won't approach this game any different to what we would do a normal Premier League 2 game, and hopefully we can come out on top.
"Everton have some got some really good young players but so have we. It's great to play in these games because you want to pit yourself against the best players and challenge yourselves."
View from the player, Lloyd Jones
"It has been a really positive season for us so far. We are top of Premier League 2, scoring a lot of goals and not conceding many, and it's good to see a lot of young lads coming through.
"Every day in training we are trying to improve and improving each other. The intensity has been really strong, we had a really good pre-season and we have taken that into the season.
"We can't wait for the mini-derby. Everton are only two points behind us in the table and it is a massive game for us. We need to win our battles all over the pitch and these are my favourite games."