Neil Critchley's side have won their opening five Premier League 2 games and will be looking to extend their lead at the top of the table.
Here is everything you need to know ahead of their latest outing...
Where is the game being played? As mentioned, the match is at Anfield, with kick-off set for 7pm BST.
Last season's head-to-head: In September 2016, the Reds produced a fantastic performance to beat Spurs 6-2 at Stevenage. Cameron Brannagan netted twice, with Trent Alexander-Arnold, Harry Wilson, Ben Woodburn and Brooks Lennon also on the mark.
Then, back in February at Anfield, Liverpool came from 2-0 down to overcome Tottenham 3-2. Wilson converted a penalty, Sheyi Ojo fired a beautiful curler into the top corner and Kevin Stewart headed in a dramatic winner.
View from the manager, Neil Critchley
"This is our second game in the space of five days and it will test the boys, but it's one we welcome and what an opportunity it is for them to play at Anfield again. It's a very special place and hopefully the boys can embrace it. I thought we were excellent from start to finish against West Ham on Monday and some of the football we played - especially in the first half - was exceptional. These players are a joy to work with every day on the training pitch. The team is important, the wins are important, but the development of our individual players is always the most important thing."
View from the player, Harry Wilson
"We have started the league season really well. That was only my second league game [against West Ham on Monday] and the lads had three great wins before that, including a couple away from home, so it gives us a great platform. We are confident with the quality we have in the team that when we go forward we can create chances and score goals. It's always special when you get the chance to play at Anfield and we are really looking forward to Friday night."